Trichloroethylene metabolism in man

Metabolism of trichloroethylene.

A major focus in the study of metabolism and disposition of trichloroethylene (TCE) is to identify metabolites that can be used reliably to assess flux through the various pathways of TCE metabolism and to identify those metabolites that are causally associated with toxic responses. Another important issue involves delineation of sex- and species-dependent differences in biotransformation pathw...

Cholesterol metabolism in man.

It has been previously demonstrated that, in the rat, the major metabolic pathway of cholesterol involves the conversion of this molecule to bile acids (1, 2). These are excreted into bile and after repeated enterohepatic circulation (3) are finally eliminated in the feces, still in the form of bile acids. Over 80 per cent of the body's cholesterol was found to be metabolized in this manner (1,...

Pyrimidine metabolism in man.

Tryptophan Metabolism in Man.

The amino acid tryptophan is unique because it contains the indole nucleus and because it is metabolized in man through several different biochemical pathways to a number of specific products. It is the precursor of serotonin and 5-hydroxyindoleacetic acid. In addition, after cleavage of the indole ring, it may be metabolized by way of the kynurenine pathway to 3-hydroxyanthranilic acid and ult...

Tryptophan Metabolism in Man * ALFRED

The amino acid tryptophan is unique because it contains the indole nucleus and because it is metabolized in man through several different biochemical pathways to a number of specific products. It is the precursor of serotonin and 5-hydroxyindoleacetic acid. In addition, after cleavage of the indole ring, it may be metabolized by way of the kynurenine pathway to 3-hydroxyanthranilic acid and ult...